How I treat and manage strokes in sickle cell disease

Neurologic complications are a major cause of morbidity and mortality in sickle
cell disease (SCD). In children with sickle cell anemia, routine use of transcranial
Doppler screening, coupled with regular blood transfusion therapy, has decreased
the prevalence of overt stroke from ∼11% to 1%.  (Blood. 2015;125(22):3401-3410)

BLOOD, 28 MAY 2015 x VOLUME 125, NUMBER 22